Drug News - Drug History - Ultimate News Database

Drug News : Drug History Database

06-07-2006 06-02-2006 05-26-2006 05-19-2006 05-15-2006 05-08-2006 05-02-2006 04-26-2006 04-14-2006 03-28-2006 03-22-2006 03-17-2006 03-14-2006 03-10-2006 03-05-2006 02-23-2006 02-16-2006 02-12-2006 02-06-2006 01-30-2006 01-24-2006 01-19-2006 01-13-2006 12-22-2005 12-14-2005 12-07-2005 11-29-2005 11-21-2005 11-16-2005 11-12-2005 11-06-2005

06/13/2006 Novartis drug shown to cut blood sugar
06/13/2006 New Osteoporosis Drug not as Cost-Effective
06/13/2006 New diabetes drugs give double punch
06/13/2006 Novartis Drug Aids Blood-Sugar Levels
06/13/2006 Afghanistan calls for regional help in war on drugs
06/13/2006 State police close to ending backlog of drug tests
06/13/2006 New drug offers hope against Alzheimer's
06/13/2006 Ex-officer charged with drug offense
06/13/2006 Panacos Initiates Phase IIb Clinical Trial of HIV Drug Candidate Bevirimat PA-457
06/13/2006 CDC Survey Measures Youth Alcohol and Drug Use among Other Risky Behaviors
06/13/2006 Free Prescription Drug Card Offers Solution to Citizens Importing Prescription Drugs
06/13/2006 Galapagos to Acquire Drug Discovery Service Operations of Discovery Partners International
06/13/2006 Drugs, jail crowding cited in burglary rise
06/12/2006 Montreal kidney cancer drug trial draws patient from Egypt
06/12/2006 Ex-guard sentenced for prison drug deal
06/12/2006 Drug Could Lower Alzheimer's Symptoms
06/12/2006 Drug to combat killer diarrhoea
06/12/2006 Study questions if drugs raise suicide risk
06/12/2006 Short course drug relieves child diarrhea
06/12/2006 Big Name Albertans Join Anti-Drug Crusade
06/12/2006 Cancer patients claim drug victory
06/12/2006 Detox drug is Georgia's new habit
06/12/2006 St Martin drug bust
06/12/2006 Trial results for diabetes drug released
06/12/2006 Cephalon partners with firm to promote sleep-disorder drug
06/12/2006 Drug Shown to Cut Diabetics' Vision Loss
06/12/2006 Trooper Makes Big Drug Bust
06/12/2006 Former police Chief pleads guilty to drug charges
06/12/2006 Drug shown to cut diabetics' vision loss
06/12/2006 TB Drug May Fight Parkinson's-like Illness
06/12/2006 FDA To Require Drug Makers To Adopt Supply Chain Tracking System
06/12/2006 Lilly drug shows promise reducing blindness in diabetics
06/12/2006 Ciba Specialty JV with Virchow Drugs
06/12/2006 2 Paths of Bayer Drug in 80 Riskier One Steered Overseas
06/12/2006 League No NHL Player Fails Drug Test
06/12/2006 Amgen cancer drug panitumumab gets FDA priority review
06/12/2006 Malawi appeals for more drugs as top AIDS officials start visit
06/12/2006 Drugs & Devices SEC Probe
06/12/2006 A New Method to Get Drugs into the Brain
06/12/2006 Depression Drugs May Up Diabetes Risk
06/12/2006 Ice-T, Common, Russell Simmons & Others Talk 'Drug Years' On New VH1 Special EbenGregory
06/12/2006 FDA Approves New Drug to Prevent Cervical Cancer
06/12/2006 SCO plans to set up anti-drug ring around Afghanistan
06/12/2006 Drug maker pleads guilty to felony counts
06/12/2006 Drug paraphernalia turns up at corner store
06/12/2006 Asthma Drugs May Boost Cataract Risk for Elderly
06/12/2006 Pharmacist is accused of stealing drugs
06/12/2006 B.C. store owners accused of selling drug pipes
06/12/2006 Unapproved drugs, by prescription
06/12/2006 US Says Drug Lords Fuel Afghan Insurgency
06/12/2006 Antidepressant approved for winter blues
06/12/2006 TB drug may fight Parkinson's-like illness
06/12/2006 Ceragenix testing bladder-cancer drug
06/12/2006 Rahul case Drug amount still mystery
06/12/2006 Rahul case Cops clueless about drugs
06/12/2006 FDA cracks down on counterfeited drugs
06/12/2006 AG, drugmaker reach settlement in Medicaid civil fraud suit
06/12/2006 Encouraging Results For Folic Acid As A Cancer Prevention Drug
06/12/2006 Abbott, drugmaker reach settlement in Medicaid fraud
06/12/2006 Police fail again, can�t fix amount of drugs
06/12/2006 Lilly Inhaled drug OK with lung disease
06/12/2006 Canadians support testing drivers for drugs poll
06/12/2006 Balkans cope with drugs, human trafficking
06/12/2006 Drug provides key to halting Alzheimer's disease in mice
06/12/2006 Police fail in drug test again, can�t fix amount
06/12/2006 FDA To Enforce Drug Tracking Law
06/12/2006 State lab catching up on drug tests
06/12/2006 New Breast Cancer Drug Aromasin, An Improvement To Current Treatments
06/12/2006 Doctors fear drug pollution poses risk to fish, people
06/12/2006 Central Asian heads meet to halt Afghan drugs flow
06/12/2006 'Hygiene better than drugs' in bird flu fight
06/12/2006 Experimental drug effective in reducing diabetic vision loss Study
06/12/2006 Lilly diabetes drug shows promise
06/12/2006 New hope for diabetics as Lilly drug claims to reduce vision loss
06/12/2006 Drug overdose treatment trial
06/12/2006 Lilly drug helps reduce diabetic vision loss study
06/12/2006 SCO to join international efforts to build anti-drug belt around
06/12/2006 Gladstone family arrested on drug charges
06/12/2006 From drug industry to global health Key exec joins Gates Foundation
06/11/2006 Diabetes drug shines in Lilly study
06/11/2006 Magnetically Guided Drug Delivery of Nanomedicine
06/11/2006 Encouraging results for folic acid as a cancer prevention drug
06/11/2006 FDA Grants Orphan Drug Desgination for Ropidoxuridine IPdR for Malignant Glioma
06/11/2006 Approval of generic drugs creates headache for the FDA
06/11/2006 FDA Unapproved Drugs are Threat to Consuming Public
06/11/2006 Trial for drug overdose treatment
06/11/2006 Lilly Drug Slows Diabetic Vision Loss
06/11/2006 Lilly Drug cuts diabetics' vision loss
06/11/2006 Lilly drug helps reduce diabetic vision loss study
06/11/2006 Lilly diabetes drug shows promise
06/11/2006 Studies Suggest Drugs Could Benefit Diabetics
06/11/2006 UK bows on breast cancer drug
06/11/2006 UK bows on breast cancer drug
06/11/2006 New drug to combat AIDS virus on the anvil
06/11/2006 Chinese Moss Extract Tested as Alzheimer's Drug
06/11/2006 Police seize large batch of drugs in Russia Urals
06/11/2006 Medicare drug plans choke independent pharmacies
06/11/2006 Coins honor anti-drug agent
06/11/2006 Doctors reluctant to up diabetes drug dosage
06/11/2006 Mainstream News Troops seize Afghan drugs stockpile
06/11/2006 High-tech drug tracking slower than hoped, US says
06/11/2006 Troops seize Afghan drugs stockpile
06/11/2006 Shorter period of taking antibiotics could avoid drug resistance
06/10/2006 Crackdown on drugs makes African students insecure
06/10/2006 Six charged with drug offences after Perth raids
06/10/2006 Drug peddlers operate openly in Lucknow
06/10/2006 Six charged with drug offences after Perth raids
06/10/2006 Drug peddlers operate openly in Lucknow
06/10/2006 The Basics In Drug Tests, Enhancements Are Needed
06/10/2006 Drug Warriors Want Eye-Eating Fungus Massively Sprayed in Colombia
06/10/2006 In Texas Town, New Drug Plan Baffles Patient and Provider Alike
06/10/2006 Fentanyl blamed for 100 drug deaths
06/10/2006 Pharmacists Object to Medicare Drug Payment System
06/10/2006 Storage receipt leads police to drug stash
06/10/2006 India�s Drug Problem
06/10/2006 Cancer Drug Ads Put Caveats in Fine Print
06/10/2006 Lilly Touts Diabetes Drug Improvements
06/10/2006 Police Juveniles helped run drug ring
06/10/2006 Yoga can keep youths away from drugs Ravi Shankar
06/10/2006 FDA says rules on prescription drug tracking will take effect in December
06/10/2006 Howell officials say parents support drug testing program
06/10/2006 At Pharmacies, New Drug Plan Is Still Baffling
06/10/2006 Four arrested on drug charges in Laconia
06/10/2006 Easier-to-use diabetes drug passes test
06/10/2006 Merck sees some hypoglycemia drug success
06/10/2006 Doctors reluctant to step up diabetes drug doses
06/10/2006 New salvo in cholesterol drug war
06/10/2006 Chicago Schoolchildren Accused Of Selling Drugs
06/10/2006 91 arrested in drug sting
06/10/2006 FDA Grants Orphan Drug Designation For CellCept in Pemphigus Vulgaris
06/10/2006 Children accused of selling drugs
06/10/2006 Legalized drugs light the way
06/10/2006 Drug mules heavy burden
06/10/2006 Police Officer target of felon, drug suspect
06/10/2006 Modified Chickens May Offer Egg Drug Potential
06/10/2006 Scores held in probe of drug smuggling
06/10/2006 NL Wire Notes Pujols' trainer denies connection to drug probe
06/09/2006 Malaysian police bust Indian drug smuggling ring
06/09/2006 DEA rounds up 91 suspects in drug sweep
06/09/2006 Bust has hurt drug trade
06/09/2006 Immigration lawyer welcomes drug, assault claims probe
06/09/2006 Malm convicted in drug-deal killing
06/09/2006 Possible Burglary Leads Authorities To Drug House
06/09/2006 Investigators suspect drug making may be the cause of house fire
06/09/2006 Prison guard sentenced for trying to smuggle drugs into prison
06/09/2006 Police 30 caught in drug ring bust
06/09/2006 Agents say roundup made dent in drug trade
06/09/2006 Safety Net For Drug Endangered Children
06/09/2006 After an 18-Year Delay, Government Tracks Prescription Drugs
06/09/2006 Statistics Indicate Marijuana No Longer Calgary's Drug Of Choice
06/09/2006 Using Google to mine MySpace for Philadelphia drug users
06/09/2006 Women's drug maker files for 1B IPO
06/09/2006 Indictments made in Seattle drug sweep
06/09/2006 FBI Wants Bonds' Ex-Girlfriend to Shun MLB Drug Probe
06/09/2006 Fri, 09 Jun 2006 173957 0400FDA Orders Unapproved Cold Remedies Pulled From Shelves Md. � In the opening salvo of an FDA initiative to cleanse the market of unapproved drugs, the agency has ordered some 120 cough and cold medicines that contain carbinomoxamine off store shelves. The two approved carbinomoxamine-containing products can continue to be sold.
06/09/2006 Country Acres drug bust
06/09/2006 FDA to require tracking of wholesale drug market to fight counterfeiting
06/09/2006 Prescribing of Antipsychotic Drugs for Children on Rise
06/09/2006 4 face drug charges
06/09/2006 Analysis Illegal drugs in pharmacies
06/09/2006 2nd Bay County Jail inmate dies from smuggled drugs
06/09/2006 Brief FDA lifts delay on enforcing drug pedigree rules
06/09/2006 U.S. Puts 5M Bounty on Drug Cartel Leader
06/09/2006 Wash. County Presents Question of Justice
06/09/2006 Traffic stop leads to drug arrest
06/09/2006 Drug maker focused on women's health files for 1B IPO
06/09/2006 FDA to require drug tracking
06/09/2006 U.S. Puts 5M Bounty Out on Drug Cartel Leader
06/09/2006 39 Million Enroll for Medicare Drug Plan
06/09/2006 GSK-Pozen drug falls short of approval
06/09/2006 Millennium asks FDA to approve cancer drug Velcade for new use
06/09/2006 Ranbaxy to sell generic epilepsy drug
06/09/2006 GSK-Posen migraine drug falls short of approval
06/09/2006 High-tech drug tracking slower than hoped, US says
06/09/2006 Elan hikes price 20% on MS drug
06/09/2006 Study Blood pressure drugs raise birth defect risk
06/09/2006 GSK, Pozen approvable for migraine drug
06/09/2006 Indiana Couple Arrested During Drug Raid
06/09/2006 FDA to ensure greater drug safety
06/09/2006 Rahul confesses to taking drugs, claim police
06/09/2006 BDSI says nausea drug's future uncertain
06/09/2006 Is green tea the next miracle drug?
06/09/2006 New Sleep Drug May Cause Fewer Side Effects
06/09/2006 Drug benefit enrollment hits 39 million
06/09/2006 Gobin drug hearing put off till June 23
06/09/2006 More Hispanic Kids Attempt Suicide, Use Drugs, Survey Says
06/09/2006 Man caught with record drug haul
06/09/2006 Breast cancer drug go-ahead
06/09/2006 Mother charged in drug overdose case
06/09/2006 Survey Hispanic Kids Lead In Suicide Attempts, Drug Use
06/09/2006 Former drug store manager sentenced for sex assaults
06/09/2006 US Offers Up to 5 Million for Reputed Mexican Drug Cartel Leader
06/09/2006 Hispanic teens lead in drug use, survey shows
06/09/2006 Herceptin wonderdrug approved for NHS
06/09/2006 Man faces life sentence in drug-deal murder
06/09/2006 Campaigner welcomes drug decision
06/09/2006 Malm convicted in drug-deal killing
06/09/2006 Blue Springs alcohol, drug checkpoint
06/09/2006 Drug Arrests
06/09/2006 Mass. man arrested on drug charges
06/09/2006 Likely drug-linked shooting leaves 3 dead, 1 wounded
06/09/2006 Watchdog approves breast cancer drug
06/09/2006 Father charged in drug-related neglect case
06/09/2006 Drug plans draw millions
06/09/2006 US drug agency approves first cervical cancer vaccine
06/09/2006 Another Inquiry Into Psychiatry's Drugs Prescribed for Invented Disorders
06/09/2006 Cancer drug approved for use on NHS
06/09/2006 NEW AIDS DRUG DEVELOPED
06/09/2006 US Approves Cervical Cancer Drug
06/08/2006 Charges made after drugs raids
06/08/2006 Ex-judge involved in drug ring gets 63 months
06/08/2006 NCB seeks to rein in foreigners Drug trade
06/08/2006 Sahil gives dope on drug cartel
06/08/2006 Busts Net ID Theft, Drug Evidence
06/08/2006 Drug-Related Deaths Hit 10-Year Low in Baltimore
06/08/2006 Mass. man arrested on drug charges
06/08/2006 Anti Drug Forum In Bethlehem
06/08/2006 Indiana bust claims 127,000 worth of illegal drugs
06/08/2006 Nigerian arrested for drug peddling
06/08/2006 High blood pressure drugs found harmful to foetus
06/08/2006 New HIV drug could stop virus from spreading
06/08/2006 1,100 drug needles found in council tax rebel's street
06/08/2006 Shropshire Four hope for drug bill victory
06/08/2006 Unapproved Drugs Called 'Threat'
06/08/2006 NHS could save .2bn by using generic cholesterol drugs
06/08/2006 Blood pressure drugs increase chances of birth defects
06/08/2006 NHS drug watchdog backs Herceptin
06/08/2006 43 charged in Naugatuck drug case
06/08/2006 Professor accused of drug trafficking remains behind bars
06/08/2006 Caregivers less likely to take drugs
06/08/2006 Des Moines Drug Dog Wins Awards
06/08/2006 US warns makers of unapproved cold medicines
06/08/2006 Survey Hispanic kids leading in suicide attempts, drug use
06/08/2006 Sanofi-Aventis to pause study enrollment
06/08/2006 Genentech drug may get out your stubbornest type of tumors
06/08/2006 HGS gets big partner for hepatitis drug
06/08/2006 HGS snags Novartis as partner for hepatitis drug
06/08/2006 Younger Men, Women Using ED Drugs
06/08/2006 Major border-to-border drug bust operation underway
06/08/2006 Major border-to-border drug bust operation underway
06/08/2006 Kidney Drug May Also Help Some Lung Cancer Patients
06/08/2006 Fourth Predix drug candidate enters clinical trials
06/08/2006 Asthma drugs increase risk of life-threatening complications
06/08/2006 End of Army support in drug war questioned
06/08/2006 Himalaya Drugs to cast retail net wider
06/08/2006 FDA gives green light to Merck cervical cancer drug
06/08/2006 Is green tea the next miracle drug?
06/08/2006 Doctor pleads guilty to drug counts
06/08/2006 Some hypertension drugs risky in early pregnancy
06/08/2006 Car Wash Owner Ponders Plea on Drug Charges
06/08/2006 Major Drug Bust in Naugatuck
06/08/2006 FDA OKs Merck cervical-cancer drug
06/08/2006 New HIV drug prevents infection of other cells
06/08/2006 How Drug Cocktails Are Changing the Way We Treat Cancer
06/08/2006 FDA halts unapproved antihistamines
06/08/2006 Report details drug company practices in marketing
06/08/2006 BP drugs, birth defects link studied
06/08/2006 Man Indicted On Gun, Drug Charges
06/08/2006 AstraZeneca/Array testing melanoma drug
06/08/2006 Former Wind River tribal judge gets prison in drug case
06/08/2006 Ovarian cancer drug being tested by Morphotek
06/08/2006 Driver In Hit-And-Run Death Reportedly Was En Route To Drug Deal
06/08/2006 Experimental Drug Activates "Death" Receptors on Cancer Cells
06/08/2006 FDA cracks down on unapproved drugs
06/08/2006 Administration of wonder fish drug begins in Andhra
06/08/2006 Blood Pressure Drugs Risky In Pregnancy, Study Says
06/08/2006 Drug And Weapons Bust Nabs Seven Suspects
06/08/2006 D'Backs hurler Grimsley tied to drug probe
06/08/2006 Study Blood pressure drugs raise birth defect risk
06/08/2006 Three face charges after undercover drug buys
06/08/2006 The Iraq War — On Drugs
06/08/2006 Drug raises risk of major birth defects
06/08/2006 Rumsfeld proposes Army pull out of U.S.-Bahamas drug effort
06/08/2006 Retired St. Paul cop surrenders in drug bust
06/08/2006 Call for drugs police gun cover
06/08/2006 Arrests after police drugs raids
06/08/2006 Several high profile people on drug peddler's list police
06/08/2006 Certain blood pressure drugs could harm fetus study
06/08/2006 Reliever is focus of new drug case
06/08/2006 Akorn Inc Gets New Drug Application Approval
06/08/2006 Springfield woman charged with drug dealing
06/08/2006 Danger found in ‘safe' drugs
06/08/2006 Blood pressure drugs are linked to birth defects
06/08/2006 County may keep drug discount program
06/08/2006 Drug for hypertension may cause birth defects study
06/08/2006 DRUG DRIVING POLL
06/08/2006 New Risk in Blood Pressure Drugs
06/08/2006 Vietnam executes five drug traffickers
06/08/2006 Attention, Doctors Drug-Free Acupressure Technique Relieves Insomnia
06/08/2006 Free Prescription Drug Card Now Available to All Americans
06/08/2006 Drug Industry Critics Examine Influence of Marketing Tactics in Hard-Hitting Documentary
06/07/2006 Glaxo seen as bidding for a unit of Pfizer
06/07/2006 Some blood-pressure drugs may cause birth defects
06/07/2006 Alberta drug smuggler jailed for 10 years
06/07/2006 Class of hypertension drugs found risky during pregnancy
06/07/2006 Study finds some blood pressure drugs raise the risk of major birth defects
06/07/2006 Editorial When Drug Firms Pay Off Competitors
06/07/2006 New Peril Is Seen in a Blood Pressure Drug
06/07/2006 Drug Smuggling Increasing Along Mexican Border
06/07/2006 A New Front in Baseballs Drug War
06/07/2006 New-generation AIDS drug to go into wider trial report
06/07/2006 Drug 'blocks the spread of HIV'
06/07/2006 Children Shot As Drug Gangs Open Fire
06/07/2006 Buffalo Mayor Takes Trip to Attack Drug Problem video included
06/07/2006 Blood pressure drugs raise risk of birth defects
06/07/2006 Meth labs down in Ore., but drug still flowing into state
06/07/2006 ACE inhibitor drugs linked to birth defects
06/07/2006 Drugs agency on track to become 'Scotland's FBI'
06/07/2006 Bosnia in major anti-drug drive
06/07/2006 Treating Cancer When a Miracle Drug Disappoints
06/07/2006 Rumsfeld Army should pull out of drug war in Bahamas
06/07/2006 Blood Pressure Drugs During Pregnancy May Up Birth Defects
06/07/2006 Miami-Caribbean Counter Drug Program May Be Pulled
06/07/2006 Study More kids using antipsychotics
06/07/2006 Widely Prescribed Drug Suspected in Murder Case
06/07/2006 Cholera Drug Tested Successfully, but Pandemic Advances
06/07/2006 St Martin drug arrest
06/07/2006 Novartis to Buy Drug Firm
06/07/2006 Rumsfeld proposes pullout on drug effort
06/07/2006 Analysis Sleep drug has brain-tumor use
06/07/2006 A new twist to Safdarjung Road drugs mystery
06/07/2006 Nastech submits new drug application for obesity to FDA
06/07/2006 Grimsley Admitted Drug Use, Says Document
06/07/2006 Roche Companies need to stockpile flu drugs
06/07/2006 Maureen's Medical Moment New drug may offer new help to people with lung cancer
06/07/2006 Food and Drug Administration Says Restaurants Should Help Reduce Obesity
06/07/2006 TB drug may help occupational parkinson's
06/07/2006 Billionaire Soros pledges 10M for drug treatment
06/07/2006 Trials for new drug to overcome HIV
06/07/2006 Drug trial results please doctors
06/07/2006 Akorn OK to sell anesthesia drug Sufenta
06/07/2006 Forensic report confirms Moitra consumed drugs
06/07/2006 Ranbaxy signs agreement with Zenotech for cancer drugs
06/07/2006 Specialty Drug Market Grows 35 Percent
06/07/2006 Drug Addicts' Kids Start Support Group
06/07/2006 Two arrested in Orissa for drug peddling
06/07/2006 Cancer Drug Ads Put Caveats in Fine Print
06/07/2006 Bowling Green Man Dies After Being Arrested On Drug Charges
06/07/2006 Drugs police swoop on Colombian gang
06/07/2006 Police widen probe in Rahul Mahajan drug case
06/07/2006 Rahul drug case Police not to take action against Apollo
06/07/2006 Ranbaxy ties up with Zenotech for cancer drugs
06/07/2006 Twelve arrested in drugs raids
06/07/2006 Better Drugs for Kidney Cancer
06/07/2006 Landmark lawsuit won over doctor's undisclosed drug problem
06/07/2006 Chandler man arrested in drug possession
06/07/2006 Novartis agrees to acquire British drug firm NeuTec Pharma
06/07/2006 Free Anti-Drug Posters from the NIDA
06/07/2006 Reid vows to get tough on drug users
06/07/2006 Fayetteville woman found competent to stand trial on drug charges
06/07/2006 OSBI agent seeks return to work after firing in drug investigation
06/07/2006 Cardiac Arrest Patients, Revived with the Help of Clot-Busting Drugs
06/07/2006 Police break suspected drugs ring
06/07/2006 Nashua man held on drug charges
06/07/2006 Nigerian arrest in Nepal reveals drug cartel
06/07/2006 Double slaying in Mesa may be drug-related
06/07/2006 Drug dogs from Iowa fare well in contest
06/07/2006 Father Shooting reveals sons drug-dealing
06/07/2006 Specialty drug spending booms
06/07/2006 Police Smash Suspected Drugs Ring
06/07/2006 Doctors' orders and licensed drug reps
06/07/2006 Contract stalemate prompts prison drug counselors' walkout
06/07/2006 Drug raids lead to arrests
06/07/2006 Police break alleged drugs ring
06/07/2006 Analysis Tysabri won't top current drugs
06/07/2006 Spending on expensive specialty drugs up 17.5%
06/07/2006 Police target drugs ring
06/07/2006 Nastech will produce drug for Procter & Gamble
06/07/2006 Schering says MS drug Betaferon approved in EU for early-stage treatment
06/07/2006 Schering says MS drug Betaferon approved in EU for early-stage treatment UPDATE
06/07/2006 Prescription drug aid center to visit
06/07/2006 Drug-testing plan on June 15 agenda
06/07/2006 Lawsuit won over doctor's undisclosed drug problem
06/07/2006 Drug trial results please doctors
06/07/2006 Woman says couple drugged her before abuse